Mathias Wilhelm studied bioinformatics (B.Sc.) and informatics in the natural sciences (M.Sc.) at the University Bielefeld. After an employment at the Harvard Medical School in the Children’s Hospital Boston in the group of Dr. Hanno Steen, he started his PhD in computational proteomics at the TUM. His dissertation was on "An in-memory platform for the exploration and analysis of big data in biology" - now known as ProteomicsDB. In 2017, he became the bioinformatics group leader at the Chair of Proteomics and Bioanalytics. In 2021, Mathias Wilhelm was appointed to the professorship for Computational Mass Spectrometry at TUM. He is a co-founder of the biotech companies OmicScouts GmbH and MSAID GmbH, both opperating in the field of proteomics.